"...Many prescription drugs damage mitochondria via a diverse range of mechanisms too complex to cover here. Among the worse are shown in Table 4. As you can see, these are all commonly prescribed.

These are all of significant concern, but particularly of concern are those prescribed frequently or taken for a long time. Some antibiotics, for example, not only impair ATP production; they also increase ROS production and damage mtDNA. The degree of mtDNA damage can be indirectly measured by 8-hydroxy-2′-deoxyguanosine (8-OHdG) in the urine. The numbers in Table 5 are cause for grave concern. This is new research from cell cultures and animals. It is reasonable to assume humans react similarly, though the research has yet to be published.9 Note especially the high level of mtDNA damage from ampicillin...."

Interesting information from NIH.  Page redirects to original and we link for educational purposes only.